Comparative Bioavailability: Two Pramipexole Formulations in Healthy Volunteers after a Single Dose Administration under Fasting Conditions
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چکیده
منابع مشابه
A Comparative Bioavailability Study of Two Ibuprofen Formulations after Single-dose Administration in Healthy Volunteers
This study was aimed to investigate the bioequivalence of ibuprofen 125 mg suppository formulation (Ibukal®, test formulation from PT. Kalbe Farma, Tbk., Jakarta) and the ibuprofen suppository comparative formulation (Proris®, from PT. Pharos Indonesia, Jakarta) in 12 healthy volunteers. The pharmacokinetic parameters used in this study were the area under the concentration-time curve from time...
متن کاملComparative Bioavailability of Two Tablet Formulations of Dipyridamole in Healthy Volunteers
The bioavailability of two dipyridamol tablet formulations of (Dipyridamole from Tolidaru and Persantin from Boehringer) was compared in 14 healthy male volunteers who received a single dose of 25 mg of the test (T) and the reference (R) products in a randomized balanced 2-way crossover design. Plasma samples were obtained over a 16 h interval and dipyridamole concentrations determined by HPLC ...
متن کاملComparative Bioavailability of Two Tablet Formulations of Dipyridamole in Healthy Volunteers
The bioavailability of two dipyridamol tablet formulations of (Dipyridamole from Tolidaru and Persantin from Boehringer) was compared in 14 healthy male volunteers who received a single dose of 25 mg of the test (T) and the reference (R) products in a randomized balanced 2-way crossover design. Plasma samples were obtained over a 16 h interval and dipyridamole concentrations determined by HPLC ...
متن کاملEffect of Hyperlipemic Food on the Comparative Bioavailability of Two Bupropion Formulations after Administration of a Single Oral Dose of 150 mg in Healthy Human Volunteers
A specific, fast and sensitive LC–MS/MS assay was developed for the determination of bupropion and its metabolite hydroxybupropion in human plasma using lidocaine as the internal standard. The limit of quantification was 3.13 ng/ml for bupropion and 7.81 ng/ml for hydroxybupropion. The method was linear in the studied range of 3.13 – 400.00 ng/ml for bupropion and 7.81 – 1000 ng/ml for hydroxyb...
متن کاملBioequivalence study of three ibuprofen formulations after single dose administration in healthy volunteers
BACKGROUND This phase I study was designed to determine the bioavailability and bioequivalence of 400 mg Eudorlin extra* (Ibuprofen) in comparison to two reference formulations (400 mg Nurofen forte and 400 mg Migränin after single dose administration under fasting conditions in healthy subjects. Therefore the design of a randomized, open label, multiple sequence cross-over study with a wash-ou...
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ژورنال
عنوان ژورنال: Journal of Bioequivalence & Bioavailability
سال: 2012
ISSN: 0975-0851
DOI: 10.4172/jbb.1000113